MLB 06: The Show was released February 28, 2006 for the PlayStation 2 and PSP. It was developed by SCE San Diego Studio and published by Sony Computer Entertainment.
The cover athlete for MLB 06: The Show is Boston Red Sox designated hitter David Ortiz. Ortiz was the 2005 American League MVP.
- "The Show" mode which is like a career mode.
- Home Run Derby is included in the All-Star Weekend.
- King of the Diamond which is an arcade style game with timed innings and a point system.
|Army of Me||Going Through Changes|
|Stab the Matador||Low Rider|
Story of the Year
|We Don't Care Anymore|
|The Black Keys||10 AM automatic|
|Transfer||Smoke of the Crowd|
|VHS or BETA||Night on Fire|
|Motion City Soundtrack||Everything is Alright|
|O.A.R.||Of a Revolution|
- Barry Bonds is not in the game because he is not in the MLBPA (Major League Baseball Players Association) so he is replaced with Reggie Stocker, a fake baseball player.